Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR1E | P28566 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659389 | 0.89 | HTR6 (0.63) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL4658392 | 0.87 | HTR6 (0.72) | HTR6HTR1AHTR2CHTR7HTR2B | |
| SCHEMBL6975334 | 0.83 | HTR6 (0.82) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL4659582 | 0.83 | CYP2C9 (0.51) | HTR6MEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL6187072 | 0.82 | HTR6 (0.54) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL615215 | 0.81 | HTR6 (0.52) | HTR6 | |
| SCHEMBL6187320 | 0.81 | HTR6 (0.58) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 | |
| Hydrochloric Acid SCHEMBL616645 | 0.80 | HTR6 (0.51) | HTR6 | |
| SCHEMBL4336114 | 0.79 | HTR3E (0.69) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL30091257 | 0.79 | HTR6 (0.55) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423106-B1 | ARYLSULFONYL DERIVATIVES WITH 5-HT 6 RECEPTOR AFFINITY | HOFFMANN LA ROCHE (CH) | 2008-12-17 | — | — | EP | disclosed |
| EP-1423106-A1 | ARYLSULFONYL DERIVATIVES WITH 5-HT 6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003014097-A1 | ARYLSULFONYL DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-20 | — | — | WO | disclosed |