Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28159208 | 0.89 | NR4A2 (0.59) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL1092934 | 0.85 | NR4A2 (1.00) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL31621504 | 0.85 | NR4A2 (1.00) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL20554177 | 0.83 | NR4A2 (0.73) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL28279140 | 0.83 | NR4A2 (0.68) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL30958431 | 0.81 | LMNA (0.68) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL2434450 | 0.81 | LMNA (0.68) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL6379635 | 0.81 | NR4A2 (0.69) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL17995258 | 0.81 | NR4A2 (0.69) | NR4A2LMNAALDH1A1KMT2AMITF | |
| SCHEMBL5137040 | 0.80 | NR4A2 (0.47) | NR4A2LMNAALDH1A1KMT2AMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153643-A | Substituted indole MCL-1 inhibitors | 范德比尔特大学 | 2019-01-04 | — | — | CN | disclosed |
| EP-1917255-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007014851-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |