Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | RASGRP1 | O95267 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15071685 | 0.90 | ALDH1A1 (0.57) | NR4A2LMNAALDH1A1MITFMAPT | |
| SCHEMBL18858380 | 0.88 | NR4A2 (0.55) | NR4A2LMNAALDH1A1MITFMAPT | |
| SCHEMBL28991624 | 0.88 | NR4A2 (0.66) | NR4A2LMNAALDH1A1MITFMAPT | |
| SCHEMBL4685270 | 0.85 | NR4A2 (0.57) | NR4A2LMNAALDH1A1MITFMAPT | |
| SCHEMBL2457012 | 0.83 | KMT2A (0.64) | NR4A2LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL27939135 | 0.83 | TSHR (0.54) | NR4A2LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL7215714 | 0.83 | TSHR (0.54) | NR4A2LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL2090257 | 0.83 | NR4A2 (0.76) | NR4A2LMNAALDH1A1NPSR1CNR1 | |
| SCHEMBL28025825 | 0.82 | NR4A2 (0.55) | NR4A2LMNAALDH1A1MITFMAPT | |
| SCHEMBL1092934 | 0.82 | NR4A2 (1.00) | NR4A2LMNAALDH1A1MITFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225895-B1 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2005-05-04 | — | — | EP | disclosed |
| US-6762201-B1 | SUCH AS N-((2-AMINO-5-(N-METHYL-N-((1-METHYLINDOL-2-YL) -METHYL)CARBAMOYL)PHENYL)METHYL)-N-METHYLACETAMIDE; BACTERIAL INFECTIONS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2004-07-13 | — | — | US | disclosed |
| EP-1225895-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-1225895-A1 | FAB I INHIBITORS | SmithKline Beecham Corporation (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026654-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | disclosed |