Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 4/20 | 0.55 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.55 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481831 | 0.91 | PDE3B (0.56) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL7349900 | 0.89 | AHR (0.53) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL16090337 | 0.83 | MAPT (0.51) | PDE3BPDE3AGRIA1CACNG8CYP1A2 | |
| SCHEMBL4481829 | 0.81 | PGR (0.58) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL689189 | 0.80 | AHR (0.50) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL4511892 | 0.80 | AHR (0.53) | GRIA1CACNG8MAOBAHRCRBN | |
| SCHEMBL4467816 | 0.79 | CRBN (0.55) | PDE3BPDE3AMAOBAHRCRBN | |
| SCHEMBL7121335 | 0.79 | AHR (0.56) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL578518 | 0.79 | AHR (0.56) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL1460158 | 0.79 | AHR (0.49) | PDE3BPDE3AGRIA1CACNG8MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001845-A2 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | LIGAND PHARMACEUTICALS, INC. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007106564-A2 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | LIGAND PHARMACEUTICALS INC. (US) | 2007-09-20 | — | — | WO | disclosed |