Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406859 | 0.94 | KMT2A (0.58) | KMT2AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL17525371 | 0.85 | KMT2A (0.52) | KMT2AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL14990248 | 0.85 | KMT2A (0.52) | KMT2AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL11947773 | 0.85 | KMT2A (0.52) | KMT2AALDH1A1KDM4EMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL4657741 | 0.80 | KMT2A (0.52) | KMT2AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL573354 | 0.79 | ALDH1A1 (0.63) | KMT2AALDH1A1KDM4ERAB9AMIF | |
| SCHEMBL272269 | 0.79 | ALDH1A1 (0.63) | KMT2AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL3490122 | 0.78 | ALDH1A1 (0.58) | KMT2AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL182243 | 0.78 | ALDH1A1 (0.61) | KMT2AALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL20583517 | 0.78 | KMT2A (0.54) | KMT2AALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |