Sugi Predict

Sugi Predict / Compounds / SCHEMBL272269

SCHEMBL272269

SCHEMBL272269

CC(C)(C)OC(=O)NN=C1CCC1

nearest known ligand 0.63

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.63
▸ KMT2A Q03164 2/20 0.63
▸ KDM4E B2RXH2 5/20 0.49
▸ RAB9A P51151 5/20 0.49
▸ MIF P14174 1/20 0.41
▸ RXFP1 Q9HBX9 1/20 0.40
▸ MAPT P10636 2/20 0.40
▸ NPC1 O15118 3/20 0.40
▸ RECQL P46063 2/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ POLB P06746 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL573354 0.96 ALDH1A1 (0.63) ALDH1A1KMT2AKDM4ERAB9AMIF
SCHEMBL12779155 0.95 ALDH1A1 (0.61) ALDH1A1KMT2AKDM4ERAB9ARXFP1
SCHEMBL182243 0.95 ALDH1A1 (0.61) ALDH1A1KMT2AKDM4ERAB9ARXFP1
SCHEMBL6694683 0.89 ALDH1A1 (0.56) ALDH1A1KMT2AKDM4ERAB9AMIF
SCHEMBL16121924 0.85 ALDH1A1 (0.56) ALDH1A1KMT2AKDM4ERAB9AMIF
SCHEMBL23782301 0.85 KDM4E (0.54) ALDH1A1KMT2AKDM4ERAB9AMAPT
SCHEMBL26177824 0.85 KDM4E (0.54) ALDH1A1KMT2AKDM4ERAB9AMAPT
SCHEMBL23782299 0.85 KDM4E (0.54) ALDH1A1KMT2AKDM4ERAB9AMAPT
SCHEMBL2672312 0.84 KMT2A (0.58) ALDH1A1KMT2AKDM4ERAB9AMIF
SCHEMBL1406859 0.84 KMT2A (0.58) ALDH1A1KMT2AKDM4ERAB9AMIF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3782994-B1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY INC (US) 2025-07-16 — — EP disclosed
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2025-03-20 — — US disclosed
US-12220401-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY, INC. (US) 2025-02-11 — — US disclosed
US-11826351-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY INC. (US) 2023-11-28 — — US disclosed
US-20230372298-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2023-11-23 — — US disclosed
US-20230301970-A1 CARBOXAMIDE DERIVATIVES NOVARTIS PHARMACEUTICALS UK LIMITED (GB) 2023-09-28 — — US disclosed
US-11672782-B2 Carboxamide derivatives NOVARTIS AG (CH) 2023-06-13 — — US disclosed
US-11471441-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY INC. (US) 2022-10-18 — — US disclosed
CN-114716381-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2022-07-08 — — CN disclosed
CN-114634447-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2022-06-17 — — CN disclosed
US-20090280083-A1 Compounds for the Treatment of Hepatitis C BRISTOL-MYERS SQUIBB COMPANY 2009-11-12 — — US disclosed
US-20090280083-A1 Compounds for the Treatment of Hepatitis C BRISTOL-MYERS SQUIBB COMPANY 2009-11-12 — — US disclosed
EP-1999114-A2 PYRAZOLES AS 11-BETA-HSD-1 F. Hoffmann-la Roche AG (CH) 2008-12-10 — — EP disclosed
WO-2007107470-A2 PYRAZOLES AS 11-BETA-HSD-1 F. HOFFMANN-LA ROCHE AG (CH) 2007-09-27 — — WO disclosed
WO-2007107470-A2 PYRAZOLES AS 11-BETA-HSD-1 F. HOFFMANN-LA ROCHE AG (CH) 2007-09-27 — — WO disclosed
US-20070225280-A1 Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase ANDERSON KEVIN WILLIAM 2007-09-27 — — US disclosed
US-20070225280-A1 Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase ANDERSON KEVIN WILLIAM 2007-09-27 — — US disclosed
US-20070225280-A1 Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase ANDERSON KEVIN WILLIAM 2007-09-27 — — US disclosed
US-5541187-A HYPOTENSIVE AGENTS STERLING WINTHROP INC. (US) 1996-07-30 — — US disclosed
US-5294612-A Hypotensive agents and cardiovascular disorders STERLING WINTHROP INC. (US) 1994-03-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070225280-A1 Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase HSD3B2, HSD3B1, HSD17B2 ALDH1A1 132/4885KMT2A 3407/4885KDM4E 2951/4885
US-12220401-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK ALDH1A1 4454/4885KMT2A 688/4885KDM4E 619/4885
US-20230301970-A1 CARBOXAMIDE DERIVATIVES SIRT1, ADCY5, ASIC1 ALDH1A1 183/4885KMT2A 733/4885KDM4E 703/4885
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK ALDH1A1 4454/4885KMT2A 688/4885KDM4E 619/4885
US-20090280083-A1 Compounds for the Treatment of Hepatitis C HAVCR2, HCCS, SLC10A1 ALDH1A1 163/4885KMT2A 4456/4885KDM4E 3736/4885
US-11826351-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK ALDH1A1 4454/4885KMT2A 688/4885KDM4E 619/4885
US-11471441-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK ALDH1A1 4454/4885KMT2A 688/4885KDM4E 619/4885
US-11672782-B2 Carboxamide derivatives SIRT5, SIRT7, ADCY5 ALDH1A1 350/4885KMT2A 683/4885KDM4E 632/4885
US-20230372298-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK ALDH1A1 4454/4885KMT2A 688/4885KDM4E 619/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.