SCHEMBL465891

SCHEMBL465891

N[C@@H](CCC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)O

nearest known ligand 0.66

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 9/20 0.66
MEN1 O00255 4/20 0.55
KMT2A Q03164 4/20 0.55
MAPT P10636 2/20 0.55
HPGD P15428 2/20 0.54
ALDH1A1 P00352 2/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
LMNA P02545 2/20 0.53
HTT P42858 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
GRM8 O00222 1/20 0.53
GRM6 O15303 1/20 0.53
GRM4 Q14833 1/20 0.53
HSP90AA1 P07900 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25334353 1.00 LTA4H (0.66) LTA4HMEN1KMT2AMAPTHPGD
Iodide SCHEMBL10947428 0.99 LTA4H (0.64) LTA4HMEN1KMT2AMAPTHPGD
Hydrochloric Acid SCHEMBL10950909 0.99 LTA4H (0.64) LTA4HMEN1KMT2AMAPTHPGD
Hydrochloric Acid SCHEMBL25433519 0.99 LTA4H (0.64) LTA4HMEN1KMT2AMAPTHPGD
Water SCHEMBL6282450 0.99 LTA4H (0.64) LTA4HMEN1KMT2AMAPTHPGD
Water SCHEMBL28456938 0.99 LTA4H (0.64) LTA4HMEN1KMT2AMAPTHPGD
Bromide SCHEMBL10946982 0.99 LTA4H (0.64) LTA4HMEN1KMT2AMAPTHPGD
SCHEMBL10776901 0.93 LTA4H (0.57) LTA4HMEN1KMT2AMAPTHPGD
SCHEMBL10776885 0.93 LTA4H (0.57) LTA4HMEN1KMT2AMAPTHPGD
SCHEMBL5696921 0.89 LTA4H (0.60) LTA4HMEN1KMT2AMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 347 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023143608-A1 COMPOSITION, METHOD FOR PREPARING SAME, AND USE THEREOF 上海复东生物医药有限责任公司 2023-08-03 WO claimed
CN-116510024-A Composition, preparation method and application thereof 上海复东生物医药有限责任公司 2023-08-01 CN claimed
US-20230220387-A1 D-SERINE TRANSPORT MODIFIER AND SCREENING METHOD THEREOF, AND SCREENING METHOD OF D-SERINE TRANSPORTER PROTEIN KAGAMI INC. (JP) 2023-07-13 US claimed
CN-112608977-B Gamma-glutamyl transpeptidase detection kit and detection method thereof 武汉伊莱瑞特生物科技股份有限公司 2022-05-10 CN claimed
EP-3760197-B1 TRANSPORT PROTEIN INHIBITOR FOR REDUCING EXPRESSION OF PD-1 INST BASIC MEDICAL SCIENCES CAMS (CN) 2022-04-27 EP claimed
US-20210283100-A1 ASCORBIC ACID, QUINONE COMPOUND, AND SODIUM GLUCOSE COTRANSPORTER INHIBITOR FOR TREATING CANCER IC MEDTECH CORP (US) 2021-09-16 US claimed
WO-2021132691-A1 D-SERINE TRANSPORT MODIFIER AND SCREENING METHOD THEREOF, AND SCREENING METHOD OF D-SERINE TRANSPORTER PROTEIN KAGAMI株式会社 2021-07-01 WO claimed
CN-112608977-A Gamma-glutamyl transpeptidase detection kit and detection method thereof 武汉伊莱瑞特生物科技股份有限公司 2021-04-06 CN claimed
EP-3490543-A1 ASCORBIC ACID, QUINONE COMPOUND, AND SODIUM GLUCOSE COTRANSPORTER INHIBITOR FOR TREATING CANCER IC-Medtech Corp. (US) 2019-06-05 EP claimed
US-10082510-B2 SRC-2 use as metabolic biomarker for diagnosis and treatment of metastatic prostate cancer BAYLOR COLLEGE OF MEDICINE (US) 2018-09-25 US claimed
US-4851572-A DIAGNOSIS OF LIVER AND BILE DUCT DISORDERS, ALCOHOLISM WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 1989-07-25 US claimed
EP-0297607-A1 Gamma-L-glutamyl-4-nitroanilide derivatives and process for determining gamma-GTP activity using the same WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 1989-01-04 EP claimed
US-4567138-A Method for determining γ-glutamyltransferase activity and kits containing a novel substrate solution for use therein BECKMAN INSTRUMENTS, INC. (US) 1986-01-28 US claimed
US-4511651-A Reagent composition and assay for the determination of γ-glutamyltransferase activity AMERICAN MONITOR CORPORATION (US) 1985-04-16 US claimed
EP-0118534-A1 METHOD FOR DETERMINING -g(g)-GLUTAMYLTRANSFERASE ACTIVITY AND KITS CONTAINING A NOVEL SUBSTRATE SOLUTION FOR USE THEREIN. BECKMAN INSTRUMENTS INC (US) 1984-09-19 EP claimed
WO-1984000978-A1 METHOD FOR DETERMINING gamma-GLUTAMYLTRANSFERASE ACTIVITY AND KITS CONTAINING A NOVEL SUBSTRATE SOLUTION FOR USE THEREIN BECKMAN INSTRUMENTS INC (US) 1984-03-15 WO claimed
US-4372874-A Stabilization of hydrolysis prone labile organic reagents in liquid media MEDICAL ANALYSIS SYSTEMS, INC. 1983-02-08 US claimed
US-4049702-A DIAGNOSIS OF LIVER DISEASE BY DETERMINATION OF G-GLUTAMYL-TRANS-PEPTIDASE BOEHRINGER MANNHEIM G.M.B.H. (DT) 1977-09-20 US claimed
US-3986931-A γ-GLUTAMYL-4-NITROANILIDE COMPOUNDS AND THEIR USE IN DETERMINING γ-GLUTAMYL TRANSPEPTIDASE BOEHRINGER MANNHEIM G.M.B.H. (DT) 1976-10-19 US claimed
US-3979447-A DETERMINATION OF G-GLUTAMYLTRANSPEPTIDASE BOEHRINGER MANNHEIM G.M.B.H. (DT) 1976-09-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210283100-A1 ASCORBIC ACID, QUINONE COMPOUND, AND SODIUM GLUCOSE COTRANSPORTER INHIBITOR FOR TREATING CANCER SLC5A1, SLC5A2, SLC5A6 LTA4H 4225/4885MEN1 937/4885KMT2A 2743/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.