Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31571593 | 1.00 | GSTP1 (0.33) | GSTP1SLC6A2SLC6A4SLC6A3HDAC4 | |
| Hydrochloric Acid SCHEMBL4659035 | 0.90 | AKR1C3 (0.31) | GSTP1AKR1C3AKR1C2S1PR4S1PR5 | |
| Hydrochloric Acid SCHEMBL4658170 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL31425740 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL1906573 | 0.86 | GSTP1 (0.35) | GSTP1SLC6A2SLC6A4SLC6A3HDAC4 | |
| Hydrochloric Acid SCHEMBL4658195 | 0.84 | HTR2A (0.31) | GSTP1SLC6A2SLC6A4SLC6A3S1PR4 | |
| Hydrochloric Acid SCHEMBL3686278 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL31571612 | 0.83 | NPC1 (0.32) | AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL4658126 | 0.83 | NPC1 (0.32) | AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL4659218 | 0.83 | HTR1A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088836-B1 | ETHYLENE/ALPHA-OLEFIN/UNCONJUGATED POLYENE COPOLYMER RUBBER, RUBBER COMPOSITION FOR SEALING, MOLDED RUBBER FOR SEALING, AND PROCESS FOR PRODUCING THE MOLDED RUBBER PART | MITSUI CHEMICALS INC (JP) | 2012-11-21 | — | — | EP | disclosed |
| EP-1640415-B1 | Olefinic thermoplastic elastomer composition and method for producing the same | MITSUI CHEMICALS INC (JP) | 2008-12-17 | — | — | EP | disclosed |
| EP-1065241-B1 | Olefinic thermoplastic elastomer composition and method for producing the same | MITSUI CHEMICALS INC (JP) | 2006-04-05 | — | — | EP | disclosed |
| EP-1640415-A2 | Olefinic thermoplastic elastomer composition and method for producing the same | MITSUI CHEMICALS, INC. (JP) | 2006-03-29 | — | — | EP | disclosed |
| US-6833045-B1 | Solid particles of graft modified ethylene/ alpha -olefin copolymer dispersed in solvent; adhesive for packaging; coatings, primers | MITSUI CHEMICALS, INC. (JP) | 2004-12-21 | — | — | US | disclosed |
| US-6635727-B1 | Random copolymer comprising structural units derived from comonomers of ethylene, one or more alpha-olefins, one or more trienes, and one or more non-conjugated polyenes in specified amounts and having specified intrinsic viscosity | MITSUI CHEMICALS, INC. (JP) | 2003-10-21 | — | — | US | disclosed |
| US-6635705-B2 | Crosslinked crystalline polyolefin resin, an ethylene-alpha-olefin-non-conjugated polyene copolymer rubber, and polyisobutylene, butyl rubber or a propylene-ethylene copolymer | MITSUI CHEMICALS, INC. (JP) | 2003-10-21 | — | — | US | disclosed |
| US-6410650-B1 | MOLDING MATERIALS | MITSUI CHEMICALS INC (JP) | 2002-06-25 | — | — | US | disclosed |
| US-20020055591-A1 | Olefinic thermoplastic elastomer composition and method for producing the same | MITSUI CHEMICALS, INC. | 2002-05-09 | — | — | US | disclosed |
| EP-1152016-A1 | ETHYLENE COPOLYMER RUBBER, PROCESS FOR PRODUCING THE SAME, AND USE | Mitsui Chemicals, Inc. (JP) | 2001-11-07 | — | — | EP | disclosed |
| EP-1088836-A1 | ETHYLENE/ALPHA-OLEFIN/UNCONJUGATED POLYENE COPOLYMER RUBBER, RUBBER COMPOSITION FOR SEALING, MOLDED RUBBER FOR SEALING, AND PROCESS FOR PRODUCING THE MOLDED RUBBER | Mitsui Chemicals, Inc. (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-1065241-A2 | Olefinic thermoplastic elastomer composition and method for producing the same | Mitsui Chemicals, Inc. (JP) | 2001-01-03 | — | — | EP | disclosed |