Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 3/20 | 0.56 |
| ▸ | KDM4A | O75164 | 2/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.56 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.56 |
| ▸ | TET3 | O43151 | 1/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 13/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1258716 | 1.00 | TET2 (0.56) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL6263449 | 0.84 | FOLH1 (0.45) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL1296430 | 0.76 | TET2 (0.61) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL7761684 | 0.75 | FOLH1 (0.47) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL28897504 | 0.75 | FOLH1 (0.51) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL19606545 | 0.74 | FOLH1 (0.44) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL28969462 | 0.73 | CYP1A2 (0.54) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL15153946 | 0.73 | TET2 (0.47) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL7607248 | 0.73 | FOLH1 (0.43) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL864236 | 0.73 | TET2 (1.00) | TET2KDM4AKDM4CKDM2ATET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406389-A1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | Agios Pharmaceuticals, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010105243-A1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |