Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 17/20 | 0.50 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18044688 | 0.86 | ADK (0.56) | ADKSLC29A1MTORRAB9AABL1 | |
| SCHEMBL23733113 | 0.86 | ADK (0.56) | ADKSLC29A1MTORRAB9A | |
| SCHEMBL4659181 | 0.86 | ADK (0.56) | ADKSLC29A1MTORRAB9A | |
| SCHEMBL18044602 | 0.86 | ADK (0.56) | ADKSLC29A1MTORRAB9AABL1 | |
| SCHEMBL29484542 | 0.85 | ADK (0.54) | ADKSLC29A1MTORRAB9AABL1 | |
| SCHEMBL16236390 | 0.85 | ADK (0.54) | ADKSLC29A1MTORRAB9AABL1 | |
| SCHEMBL1939761 | 0.82 | ADK (0.52) | ADKSLC29A1MTORRAB9AABL1 | |
| SCHEMBL401328 | 0.82 | ADK (0.52) | ADKSLC29A1MTORRAB9AABL1 | |
| SCHEMBL18044604 | 0.82 | ADK (0.52) | ADKSLC29A1MTORRAB9ACHEK1 | |
| SCHEMBL398109 | 0.82 | ADK (0.57) | ADKSLC29A1MTORRAB9AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004651-A2 | NOVEL CYCLOBUTYL COMPOUNDS AS KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007115620-A2 | NOVEL CYCLOBUTYL COMPOUNDS AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |