SCHEMBL4659255

SCHEMBL4659255

COc1ncc(N)cc1-c1ccnn1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 2/20 0.40
MAPT P10636 2/20 0.38
ALDH1A1 P00352 1/20 0.38
AURKA O14965 1/20 0.37
TTK P33981 1/20 0.37
AURKB Q96GD4 1/20 0.37
INCENP Q9NQS7 1/20 0.37
HTR2A P28223 2/20 0.37
HTR2C P28335 2/20 0.37
LRRK2 Q5S007 1/20 0.36
ROCK2 O75116 1/20 0.36
ROCK1 Q13464 1/20 0.36
CDC42BPB Q9Y5S2 1/20 0.36
GRM7 Q14831 1/20 0.36
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP19A1 P11511 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4724799 0.79 KCNH2 (0.47) HTR2AHTR2C
SCHEMBL4661803 0.78 KAT2B (0.39) DRD1MAPTALDH1A1HTR2AHTR2C
SCHEMBL14397723 0.78 HTR2A (0.38) HTR2AHTR2CROCK2ROCK1CDC42BPB
SCHEMBL4724119 0.77 HTR2A (0.48) HTR2AHTR2C
SCHEMBL1166433 0.76 HTR2A (0.52) MAPTALDH1A1HTR2AHTR2CLRRK2
SCHEMBL4791807 0.73 MKNK1 (0.41) ROCK2ROCK1CDC42BPBACVR1ADRA1A
SCHEMBL16442403 0.73 IMPDH2 (0.49) MAPTALDH1A1HTR2AHTR2CLRRK2
SCHEMBL4660667 0.72 HTR2A (0.40) ALDH1A1HTR2AHTR2CCYP1A2CYP3A4
SCHEMBL4659261 0.72 HTR2A (0.40) HTR2AHTR2C
SCHEMBL31165734 0.72 AURKA (0.59) MAPTAURKATTKAURKBINCENP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2004627-A2 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2008-12-24 EP disclosed
WO-2007120600-A2 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2007-10-25 WO disclosed
WO-2007120600-A2 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2007-10-25 WO disclosed