Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28430136 | 0.79 | CFTR (0.57) | BRD4LMNAALDH1A1KMT2A | |
| SCHEMBL29388744 | 0.79 | CFTR (0.57) | BRD4LMNAALDH1A1KMT2A | |
| SCHEMBL29386548 | 0.77 | CFTR (0.55) | BRD4LMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28433786 | 0.77 | CFTR (0.55) | BRD4LMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4311048 | 0.74 | SCD (0.51) | BRD4ALDH1A1 | |
| SCHEMBL17184347 | 0.73 | CFTR (0.59) | BRD4LMNAALDH1A1MAPTPOLB | |
| SCHEMBL4316776 | 0.71 | SCD (0.48) | BRD4ALDH1A1 | |
| SCHEMBL5036280 | 0.70 | HTT (0.59) | BRD4KDM4ELMNAHTTALDH1A1 | |
| SCHEMBL4311696 | 0.70 | CCR9 (0.48) | BRD4ALDH1A1 | |
| SCHEMBL28430587 | 0.69 | USP2 (0.49) | BRD4LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004193-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007108968-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2007-09-27 | — | — | WO | disclosed |