Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.65 |
| ▸ | DRD4 | P21917 | 2/20 | 0.65 |
| ▸ | DRD3 | P35462 | 2/20 | 0.65 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847565 | 0.85 | DRD2 (0.59) | DRD2DRD4DRD3P2RX7TDP1 | |
| SCHEMBL29832319 | 0.81 | DRD2 (0.71) | DRD2DRD4DRD3P2RX7TDP1 | |
| SCHEMBL11711278 | 0.80 | DRD2 (0.69) | DRD2DRD4DRD3P2RX7TDP1 | |
| SCHEMBL15748185 | 0.79 | DRD3 (1.00) | DRD2DRD4DRD3P2RX7TDP1 | |
| SCHEMBL11507200 | 0.79 | CCR3 (0.57) | DRD2DRD4DRD3 | |
| SCHEMBL9814242 | 0.78 | TDP1 (0.84) | DRD2DRD4DRD3TDP1LMNA | |
| SCHEMBL30294105 | 0.78 | TDP1 (0.84) | DRD2DRD4DRD3TDP1LMNA | |
| SCHEMBL5337194 | 0.77 | DRD2 (0.62) | DRD2DRD4DRD3P2RX7TDP1 | |
| SCHEMBL11712233 | 0.77 | DRD2 (0.65) | DRD2DRD4DRD3P2RX7TDP1 | |
| SCHEMBL30150452 | 0.77 | TDP1 (0.81) | DRD2DRD4DRD3TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004613-A2 | BICYCLIC BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2008-12-24 | — | — | EP | claimed |
| WO-2007115077-A2 | BICYCLIC BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | claimed |