SCHEMBL5847565

SCHEMBL5847565

OC1(c2ccccc2)CCN(CCCCn2cnc3ccccc32)CC1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 3/20 0.59
DRD4 P21917 2/20 0.59
DRD3 P35462 2/20 0.59
P2RX7 Q99572 1/20 0.59
SIGMAR1 Q99720 1/20 0.55
LMNA P02545 2/20 0.52
ALOX15 P16050 1/20 0.52
TSHR P16473 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
TDP1 Q9NUW8 1/20 0.50
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
KMT2A Q03164 1/20 0.49
CCR3 P51677 1/20 0.49
OPRL1 P41146 2/20 0.49
CCR1 P32246 2/20 0.48
EGLN3 Q9H6Z9 1/20 0.48
HTT P42858 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5846850 0.91 SMN1; SMN2 (0.56) DRD2DRD4DRD3P2RX7LMNA
SCHEMBL5846289 0.91 CCR1 (0.55) DRD2DRD4DRD3P2RX7SIGMAR1
SCHEMBL11507200 0.89 CCR3 (0.57) DRD2DRD4DRD3CCR3OPRL1
SCHEMBL4660429 0.85 DRD2 (0.65) DRD2DRD4DRD3P2RX7LMNA
SCHEMBL5847870 0.81 SIGMAR1 (0.53) DRD2SIGMAR1LMNAMEN1ALDH1A1
SCHEMBL11712233 0.78 DRD2 (0.65) DRD2DRD4DRD3P2RX7LMNA
SCHEMBL5847529 0.78 SIGMAR1 (0.58) DRD2DRD4DRD3P2RX7SIGMAR1
SCHEMBL3161153 0.77 TDP1 (0.84) DRD2DRD4DRD3P2RX7LMNA
SCHEMBL29832319 0.76 DRD2 (0.71) DRD2DRD4DRD3P2RX7LMNA
SCHEMBL11062805 0.76 SIGMAR1 (0.70) DRD2SIGMAR1LMNAMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39113-E1 Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain LABORATORIES DEL DR. ESTEVE, S.A. (ES) 2006-05-30 US claimed
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
CN-1120167-C Tetrahydropyridine-(or 4-hydroxypiperidine) Alkylazoles having an affinity for sigma and/or 5HTIA receptors ESTEVE S A LAB DE DR (ES) 2003-09-03 CN claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed
CN-1166173-A Tetrahydropyridine- (or 4-hydroxypiperidine) alkylpyrroles active at sigma and/or 5HTIA receptors ESTEVE S A LAB DE DR (ES) 1997-11-26 CN claimed
EP-0721455-A1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1996-07-17 EP claimed
WO-1996004287-A1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1996-02-15 WO claimed
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP disclosed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP disclosed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US disclosed
US-5731331-A Tetrahydropyridine-(or 4-hydroxypiperidine) alkylazoles LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1998-03-24 US disclosed