SCHEMBL4661233

SCHEMBL4661233

CN(Cc1cnc2ccccc2c1)c1ccccc1CCO

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.40
EPAS1 Q99814 1/20 0.40
PTGES O14684 1/20 0.40
ALOX5 P09917 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
CFTR P13569 1/20 0.39
TRPM8 Q7Z2W7 1/20 0.38
CYP1A2 P05177 2/20 0.38
PDE10A Q9Y233 6/20 0.38
KDM4E B2RXH2 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4662731 0.77 PTPN1 (0.34) HDAC1KDM4EALDH1A1LMNARAB9A
SCHEMBL28339089 0.76 TDP1 (0.45) KDM4EALDH1A1RAB9ANPC1TSHR
SCHEMBL5546916 0.76 ALDH1A1 (0.50) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4661367 0.72 ACACB (0.42)
SCHEMBL4661308 0.72 ALDH1A1 (0.39) KDM4EALDH1A1LMNAHTTSMN1; SMN2
SCHEMBL27313180 0.70 NPSR1 (0.49) HIF1AEPAS1PTGESALOX5CFTR
SCHEMBL272057 0.70 ALDH1A1 (0.47) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL14252997 0.70 HIF1A (0.46) HIF1AEPAS1PTGESALOX5CFTR
SCHEMBL7210199 0.70 CYP1A2 (0.46) HIF1AEPAS1PTGESALOX5CFTR
SCHEMBL701411 0.70 ALDH1A1 (0.53) CFTRCYP1A2PDE10AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2007707-A1 COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR Boehringer Ingelheim International GmbH (DE) 2008-12-31 EP disclosed
WO-2007118041-A1 COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-10-18 WO disclosed