Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 13/20 | 0.54 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.54 |
| ▸ | SLC34A3 | Q8N130 | 1/20 | 0.54 |
| ▸ | SLC20A1 | Q8WUM9 | 1/20 | 0.54 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.42 |
| ▸ | ADCYAP1R1 | P41586 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15421200 | 1.00 | SLC34A2 (0.54) | SLC34A2SLC34A1SLC34A3SLC20A1HSPH1 | |
| SCHEMBL46938 | 0.89 | SLC34A2 (0.44) | SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1 | |
| SCHEMBL15421039 | 0.89 | SLC34A2 (0.44) | SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1 | |
| SCHEMBL268180 | 0.86 | SLC34A2 (0.57) | SLC34A2SLC34A1SLC34A3SLC20A1HSPH1 | |
| SCHEMBL268179 | 0.86 | SLC34A2 (0.57) | SLC34A2SLC34A1SLC34A3SLC20A1HSPH1 | |
| SCHEMBL273926 | 0.86 | SLC34A2 (0.57) | SLC34A2SLC34A1SLC34A3SLC20A1HSPH1 | |
| SCHEMBL268892 | 0.85 | SLC34A2 (0.56) | SLC34A2SLC34A1SLC34A3SLC20A1HSPH1 | |
| SCHEMBL274282 | 0.85 | SLC34A2 (0.56) | SLC34A2SLC34A1SLC34A3SLC20A1HSPH1 | |
| SCHEMBL268893 | 0.85 | SLC34A2 (0.56) | SLC34A2SLC34A1SLC34A3SLC20A1HSPH1 | |
| SCHEMBL268320 | 0.83 | SLC34A2 (0.78) | SLC34A2SLC34A1SLC34A3SLC20A1HSPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |
| US-20140023611-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. | 2014-01-23 | — | — | US | disclosed |
| US-20140023611-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. | 2014-01-23 | — | — | US | disclosed |
| US-20140023611-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. | 2014-01-23 | — | — | US | disclosed |
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140023611-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | SLC10A2, SLC34A2, SLC34A3 | SLC34A2 2/4885SLC34A1 4/4885SLC34A3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.