Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL552657 | 0.93 | POLB (0.47) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL10211381 | 0.90 | POLB (0.45) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL13322052 | 0.89 | POLB (0.48) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL10211383 | 0.86 | TSHR (0.46) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL23063876 | 0.84 | GPR119 (0.48) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL14693395 | 0.83 | POLB (0.46) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL29723775 | 0.82 | GPR119 (0.50) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL27181889 | 0.82 | GPR119 (0.50) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL10267719 | 0.82 | POLB (0.37) | POLBALDH1A1GAAPKMHSD17B10 | |
| SCHEMBL4667607 | 0.81 | USP30 (0.40) | ESR2GPR119NR1H2UCHL1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293802-A1 | Chemical Compounds | SMITHLINE BEECHAM CORPORATION | 2008-11-27 | — | — | US | disclosed |
| US-20080293802-A1 | Chemical Compounds | SMITHLINE BEECHAM CORPORATION | 2008-11-27 | — | — | US | disclosed |
| US-20080293802-A1 | Chemical Compounds | SMITHLINE BEECHAM CORPORATION | 2008-11-27 | — | — | US | disclosed |
| WO-2007076286-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293802-A1 | Chemical Compounds | IKBKG, NFKBIA, IDO2 | POLB 1978/4885ALDH1A1 2429/4885GAA 4166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.