Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600237 | 0.91 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL14600443 | 0.89 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL14600238 | 0.89 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL14600240 | 0.88 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL14600243 | 0.87 | GFER (0.53) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL14600246 | 0.84 | MAPK13 (0.53) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL5008471 | 0.81 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL5008332 | 0.81 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL3939655 | 0.81 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL14600236 | 0.81 | MAPK13 (0.56) | MAPK14MAPK13MAPK12MAPK11CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928455-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | Bayer Healthcare, LLC (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |