Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4148484 | 0.86 | LMNA (0.40) | LMNAHTR1DHTR7HTR1AFAAH | |
| SCHEMBL13102476 | 0.84 | LMNA (0.47) | FYNLMNAHTR1DHTR7HTR1A | |
| SCHEMBL4144409 | 0.82 | TSHR (0.38) | LMNAHTR1DDRD2DRD1 | |
| SCHEMBL4136458 | 0.81 | HRH3 (0.45) | FYNLMNAHTR1DHTR7HTR1A | |
| SCHEMBL4136016 | 0.81 | HTR1D (0.41) | FYNLMNAHTR1DHTR7HTR1A | |
| SCHEMBL4141070 | 0.80 | HTR1A (0.41) | HTR1DHTR7HTR1AGRIN2BDRD2 | |
| SCHEMBL4136422 | 0.80 | HTR1A (0.41) | LMNAHTR1DHTR7HTR1AFAAH | |
| SCHEMBL4147479 | 0.79 | FYN (0.44) | FYNHTR1DHTR7HTR1AFAAH | |
| SCHEMBL20909692 | 0.78 | LMNA (0.52) | LMNAHTR1DFAAHGRIN2BDRD2 | |
| SCHEMBL4137087 | 0.78 | HTR1D (0.41) | FYNLMNAHTR1DHTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007749-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | Pfizer Products Inc. (US) | 2008-12-31 | — | — | EP | claimed |
| WO-2007105053-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | claimed |