Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 2/20 | 0.49 |
| ▸ | TK1 | P04183 | 1/20 | 0.41 |
| ▸ | TK2 | O00142 | 12/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560477 | 0.97 | DUT (0.53) | DUTTK1TK2CYP2C9KMT2A | |
| SCHEMBL13314164 | 0.81 | CYP1A2 (0.48) | TK1TK2CYP2C9KMT2AMAPT | |
| SCHEMBL3559057 | 0.80 | CYP2C9 (0.42) | TK1TK2CYP2C9KMT2AMAPT | |
| SCHEMBL13314163 | 0.80 | ALDH1A1 (0.43) | TK1TK2CYP2C9KMT2AMAPT | |
| SCHEMBL3565020 | 0.77 | TK2 (0.37) | TK1TK2CYP2C9KMT2AMAPT | |
| SCHEMBL3557780 | 0.74 | MAPK1 (0.35) | TK1TK2 | |
| SCHEMBL3565717 | 0.74 | DUT (0.54) | DUTTK1TK2CYP2C9KMT2A | |
| SCHEMBL19181080 | 0.72 | TYMP (0.52) | DUTTK1TK2 | |
| SCHEMBL3566318 | 0.70 | DUT (0.58) | DUTTK1TK2CYP2C9KMT2A | |
| SCHEMBL9354252 | 0.70 | DUT (0.55) | DUTTK1TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007750-B1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LTD (GB) | 2013-08-21 | — | — | EP | disclosed |
| EP-2007750-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007113232-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007113232-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | WO | disclosed |