Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | ACACB | O00763 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560316 | 0.81 | MRGPRX4 (0.49) | MRGPRX4HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL4461433 | 0.78 | ROCK1 (0.55) | HDAC3HDAC4HDAC1HDAC6CYP2C9 | |
| SCHEMBL5560314 | 0.76 | MRGPRX4 (0.47) | MRGPRX4MMP1MMP2MMP9MMP14 | |
| SCHEMBL4463963 | 0.75 | HDAC3 (0.53) | PDE2AHDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL4664658 | 0.75 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6CYP2C9 | |
| SCHEMBL6030791 | 0.75 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6CYP2C9 | |
| SCHEMBL6030794 | 0.75 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6CYP2C9 | |
| SCHEMBL5046005 | 0.74 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC6CYP2C9 | |
| SCHEMBL5046007 | 0.74 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC6CYP2C9 | |
| SCHEMBL27678084 | 0.74 | RXRA (0.51) | MRGPRX4PTGER4ACACBMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423060-B2 | Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | US | disclosed |
| EP-1758881-A1 | THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121120-A1 | THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | HDAC1, HDAC5, HDAC2 | MRGPRX4 4650/4885PDE2A 2533/4885HDAC3 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.