SCHEMBL4665290

SCHEMBL4665290

N=C1OCCN1c1ccc(NC(=O)c2ccc(C(F)(F)F)cc2N(CS(=O)(=O)O)C(=O)c2ccc(Cl)s2)cc1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
F10 P00742 14/20 0.40
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
KMT2A Q03164 1/20 0.38
HIF1A Q16665 1/20 0.37
EPAS1 Q99814 1/20 0.37
TRPV4 Q9HBA0 2/20 0.37
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
AVPR2 P30518 1/20 0.35
GPR27 Q9NS67 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4665046 0.90 F10 (0.42) F10MEN1ALDH1A1MAPTHTT
SCHEMBL4667932 0.90 F10 (0.43) F10MEN1ALDH1A1MAPTHTT
SCHEMBL4663209 0.89 F10 (0.42) F10MEN1ALDH1A1MAPTHTT
SCHEMBL4667334 0.88 F10 (0.50) F10MEN1ALDH1A1MAPTHTT
SCHEMBL4665199 0.87 F10 (0.40) F10MEN1ALDH1A1MAPTHTT
SCHEMBL4666914 0.87 F10 (0.48) F10MEN1ALDH1A1MAPTHTT
SCHEMBL4667573 0.87 F10 (0.40) F10MEN1ALDH1A1MAPTHTT
SCHEMBL3617881 0.85 F10 (0.45) F10MEN1ALDH1A1MAPTHTT
SCHEMBL4632553 0.85 F10 (0.43) F10MEN1ALDH1A1MAPTHTT
SCHEMBL4632548 0.84 F10 (0.40) F10MEN1ALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1928868-A1 IMINOOXAZOLIDINE DERIVATIVES AND USE THEREOF Bayer HealthCare AG (DE) 2008-06-11 EP disclosed
WO-2007028520-A1 IMINOOXAZOLIDINE DERIVATIVES AND USE THEREOF BAYER HEALTHCARE AG (DE) 2007-03-15 WO disclosed