Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600184 | 0.93 | ADORA1 (0.49) | RAF1BRAFMAPK14PTK2PTK2B | |
| SCHEMBL5008532 | 0.89 | MAPK14 (0.47) | MAPK14PTK2PTK2BMAPK12MAPK13 | |
| SCHEMBL5008723 | 0.83 | MAPK14 (0.46) | MAPK14PTK2PTK2BMAPK12MAPK13 | |
| SCHEMBL4667080 | 0.81 | GFER (0.57) | ADORA1 | |
| SCHEMBL5012222 | 0.80 | ADORA1 (0.62) | MAPK14MAPK12MAPK13MAPK11ADORA1 | |
| SCHEMBL14600217 | 0.80 | MAPK14 (0.50) | RAF1BRAFMAPK14MAPK12MAPK13 | |
| SCHEMBL5008440 | 0.79 | MAPK14 (0.45) | MAPK14PTK2PTK2BMAPK12MAPK13 | |
| SCHEMBL5008388 | 0.79 | MAPK14 (0.53) | BRAFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5007711 | 0.79 | MAPK14 (0.47) | RAF1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL14600243 | 0.78 | GFER (0.53) | MAPK14PTK2MAPK12MAPK13MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928455-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | Bayer Healthcare, LLC (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |