Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 9/20 | 0.53 |
| ▸ | BCL2 | P10415 | 2/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.53 |
| ▸ | BAD | Q92934 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | F9 | P00740 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4634984 | 0.88 | LMNA (0.45) | MCL1BCL2BCL2L1BADLMNA | |
| SCHEMBL4633609 | 0.88 | LMNA (0.54) | MCL1BCL2BCL2L1BADLMNA | |
| SCHEMBL4634058 | 0.85 | MAPT (0.59) | MCL1BCL2BCL2L1BADLMNA | |
| SCHEMBL4635043 | 0.84 | CXCR2 (0.55) | MCL1BCL2BCL2L1BADLMNA | |
| SCHEMBL4633878 | 0.83 | CXCR2 (0.46) | LMNAGAAMAPTNPSR1L3MBTL1 | |
| SCHEMBL4633540 | 0.81 | CXCR2 (0.51) | MCL1BCL2BCL2L1BADLMNA | |
| SCHEMBL4633576 | 0.81 | KMT2A (0.50) | MCL1BCL2BCL2L1BADLMNA | |
| SCHEMBL4633952 | 0.79 | CXCR2 (0.44) | LMNAGAAMAPTNPSR1L3MBTL1 | |
| SCHEMBL4632910 | 0.78 | KMT2A (0.52) | LMNAGAAMAPTNPSR1L3MBTL1 | |
| SCHEMBL4635087 | 0.78 | MCL1 (0.70) | MCL1BCL2BCL2L1BADALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685121-B1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | claimed |