SCHEMBL4666145

SCHEMBL4666145

CC(=O)Oc1ccc(-c2ccc(OS(N)(=O)=O)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
STS P08842 7/20 0.61
CA2 P00918 9/20 0.59
CA9 Q16790 9/20 0.59
CA1 P00915 8/20 0.59
HSD17B10 Q99714 1/20 0.56
POLB P06746 1/20 0.55
MAPT P10636 1/20 0.55
PKM P14618 1/20 0.55
KIF11 P52732 1/20 0.53
CA12 O43570 2/20 0.53
LMNA P02545 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL329365 0.82 HSD17B10 (0.76) HSD17B10POLBMAPTPKMLMNA
SCHEMBL9158246 0.82 HSD17B10 (0.76) HSD17B10POLBMAPTPKMLMNA
Water SCHEMBL9344643 0.80 HSD17B10 (0.73) HSD17B10POLBMAPTPKMLMNA
SCHEMBL4665404 0.78 CA1 (0.90) STSCA2CA9CA1CA12
SCHEMBL3790234 0.77 HSD17B10 (0.63) HSD17B10POLBMAPTPKMLMNA
SCHEMBL4668682 0.77 CA2 (0.88) STSCA2CA9CA1KIF11
SCHEMBL6800066 0.77 CA2 (0.68) STSCA2CA9CA1KIF11
SCHEMBL4665408 0.77 CA2 (0.68) STSCA2CA9CA1KIF11
SCHEMBL4665396 0.77 CA2 (0.88) STSCA2CA9CA1KIF11
SCHEMBL27207781 0.77 MAPT (0.62) STSHSD17B10POLBMAPTPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1193250-B1 PHENYL SULFAMATE DERIVATIVES TEIKOKU HORMONE MFG CO LTD (JP) 2008-06-04 EP disclosed
US-6762205-B1 STEROID SULFATASE INHIBITORS WITHOUT ESTROGENIC SIDE EFFECT ACTION TEIKOKU HORMONE MFG. CO., LTD. (JP) 2004-07-13 US disclosed
EP-1193250-A1 PHENYL SULFAMATE DERIVATIVES Teikoku Hormone Mfg. Co., Ltd. (JP) 2002-04-03 EP disclosed