Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 18/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 18/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 18/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 18/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 18/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 18/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 18/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 18/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4666588 | 1.00 | ITGB2 (0.45) | ITGB2ICAM1ITGALHDAC3HDAC4 | |
| SCHEMBL4669105 | 0.86 | HDAC1 (0.37) | ITGB2ICAM1ITGALHDAC3HDAC4 | |
| SCHEMBL4669110 | 0.86 | HDAC1 (0.37) | ITGB2ICAM1ITGALHDAC3HDAC4 | |
| SCHEMBL4348358 | 0.85 | HDAC3 (0.45) | ITGB2ICAM1ITGALHDAC3HDAC4 | |
| SCHEMBL4348370 | 0.85 | HDAC3 (0.45) | ITGB2ICAM1ITGALHDAC3HDAC4 | |
| SCHEMBL4668044 | 0.85 | GSK3B (0.43) | — | |
| SCHEMBL4668041 | 0.85 | GSK3B (0.43) | — | |
| SCHEMBL4667789 | 0.80 | PTPN2 (0.37) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4667795 | 0.80 | PTPN2 (0.37) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4668013 | 0.80 | TAS1R3 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | claimed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | claimed |
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | disclosed |