Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.62 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.62 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.62 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.52 |
| ▸ | ST6GAL1 | P15907 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13524621 | 0.92 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL15338532 | 0.92 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL14178411 | 0.92 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL2811458 | 0.92 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL18231346 | 0.92 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL158513 | 0.92 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL383499 | 0.92 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL17304691 | 0.92 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL27735995 | 0.85 | LMNA (0.65) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL24829650 | 0.84 | LMNA (0.59) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915053-A2 | NOVEL 2'-C-METHYL AND 4'-C-METHYL NUCLEOSIDE DERIVATIVES | Merck & Co., Inc. (US) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007022073-A2 | NOVEL 2'-C-METHYL AND 4'-C-METHYL NUCLEOSIDE DERIVATIVES | MERCK & CO., INC. (US) | 2007-02-22 | — | — | WO | disclosed |