Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CDA | P32320 | 1/20 | 0.50 |
| ▸ | PYGL | P06737 | 3/20 | 0.46 |
| ▸ | SLC5A2 | P31639 | 5/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421045 | 1.00 | MAPT (0.50) | MAPTCDAPYGLSLC5A2HIF1A | |
| SCHEMBL6785146 | 1.00 | MAPT (0.50) | MAPTCDAPYGLSLC5A2HIF1A | |
| SCHEMBL7199367 | 1.00 | MAPT (0.50) | MAPTCDAPYGLSLC5A2HIF1A | |
| SCHEMBL8722212 | 1.00 | MAPT (0.50) | MAPTCDAPYGLSLC5A2HIF1A | |
| SCHEMBL1525779 | 1.00 | MAPT (0.50) | MAPTCDAPYGLSLC5A2HIF1A | |
| SCHEMBL6784675 | 1.00 | MAPT (0.50) | MAPTCDAPYGLSLC5A2HIF1A | |
| SCHEMBL6927896 | 1.00 | MAPT (0.50) | MAPTCDAPYGLSLC5A2HIF1A | |
| SCHEMBL28147525 | 0.85 | HIF1A (0.45) | MAPTCDAPYGLSLC5A2HIF1A | |
| SCHEMBL2185181 | 0.84 | CDA (0.43) | MAPTCDAPYGLSLC5A2 | |
| SCHEMBL5010368 | 0.84 | CDA (0.43) | MAPTCDAPYGLSLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928475-A2 | ANTIVIRAL PHOSPHORAMIDATES OF 4'-SUBSTITUTED PRONUCLEOTIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| EP-1794172-A1 | ANTIVIRAL 4'-AZIDO-NUCLEOSIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007020193-A2 | ANTIVIRAL PHOSPHORAMIDATES OF 4 ' -SUBSTITUTED PRONUCLEOTIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |
| WO-2006021341-A1 | ANTIVIRAL 4’-AZIDO-NUCLEOSIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-02 | — | — | WO | disclosed |