Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468870 | 0.75 | IDO1 (0.40) | CYP19A1ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL28758851 | 0.75 | IDO1 (0.44) | ALDH1A1 | |
| SCHEMBL27164548 | 0.74 | ALDH1A1 (0.39) | CYP19A1SMN1; SMN2TLR8TLR7ALDH1A1 | |
| SCHEMBL2153612 | 0.74 | CYP19A1 (0.48) | CYP19A1SMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL2825597 | 0.72 | DPP4 (0.43) | SLC6A4 | |
| SCHEMBL2727911 | 0.71 | CYP19A1 (0.45) | CYP19A1SMN1; SMN2ALDH1A1MAPTALOX15 | |
| SCHEMBL11294215 | 0.71 | ALDH1A1 (0.40) | CYP19A1ALDH1A1MAPTSLC6A4 | |
| SCHEMBL1931499 | 0.70 | HSPA5 (0.37) | SMN1; SMN2ALDH1A1MAPTALOX15HSD17B10 | |
| SCHEMBL27164067 | 0.70 | TSHR (0.39) | CYP19A1SMN1; SMN2ALDH1A1MAPTPLAU | |
| SCHEMBL2903299 | 0.69 | HRH3 (0.50) | CYP19A1TLR8TLR7ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871750-A1 | IMPROVED PROCESS FOR THE PREPARATION OF LETROZOLE | Sicor, Inc. (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2007100346-A1 | IMPROVED PROCESS FOR THE PREPARATION OF LETROZOLE | SICOR, INC. (US) | 2007-09-07 | — | — | WO | claimed |