Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767382 | 0.81 | HRH3 (0.45) | HRH3CYP19A1DAOKMT2A | |
| SCHEMBL31132412 | 0.76 | HTR1B (0.45) | IDH1GABRG2GABRB3GABRA3MAPT | |
| SCHEMBL28758849 | 0.76 | IDO1 (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL2153847 | 0.76 | HRH3 (0.59) | HRH3MPOGLACYP19A1CYP11B1 | |
| SCHEMBL29272 | 0.75 | ALDH1A1 (0.46) | HRH3ALDH1A1MAPTMEN1TSHR | |
| Benzene SCHEMBL27499662 | 0.75 | ALDH1A1 (0.46) | HRH3ALDH1A1MAPTMEN1TSHR | |
| SCHEMBL28758850 | 0.74 | HTR1B (0.50) | DAO | |
| SCHEMBL22968664 | 0.74 | HRH3 (0.55) | HRH3MPOGLACYP19A1CYP11B1 | |
| SCHEMBL29467167 | 0.74 | HRH3 (0.55) | HRH3MPOGLACYP19A1CYP11B1 | |
| SCHEMBL9508013 | 0.73 | ALDH1A1 (0.44) | HRH3ALDH1A1MAPTMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212301-A1 | AN IMPROVED PROCESS FOR PREPARATION OF LETROZOLE AND ITS INTERMEDIATES | Fresenius Kabi Oncology Limited (IN) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009069140-A1 | AN IMPROVED PROCESS FOR PREPARATION OF LETROZOLE AND ITS INTERMEDIATES | DABUR PHARMA LIMITED (IN) | 2009-06-04 | — | — | WO | disclosed |