Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30123241 | 1.00 | OPRM1 (0.56) | OPRM1OPRD1CHRM1 | |
| SCHEMBL30123761 | 0.83 | OPRM1 (0.65) | OPRM1OPRD1 | |
| SCHEMBL4554890 | 0.83 | OPRM1 (0.65) | OPRM1OPRD1 | |
| SCHEMBL1761203 | 0.80 | OPRM1 (0.64) | OPRM1OPRD1 | |
| SCHEMBL25237180 | 0.80 | OPRM1 (0.61) | OPRM1OPRD1 | |
| SCHEMBL1845855 | 0.79 | OPRM1 (0.72) | OPRM1OPRD1 | |
| SCHEMBL4668869 | 0.78 | SLC6A3 (0.55) | OPRM1OPRD1CHRM1 | |
| SCHEMBL1847502 | 0.77 | OPRM1 (0.57) | OPRM1OPRD1 | |
| SCHEMBL3652383 | 0.75 | SLC18A3 (0.39) | OPRM1OPRD1 | |
| SCHEMBL4666909 | 0.75 | OPRM1 (0.41) | OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001876-A2 | 8-AZABICYCLOÝ3.2.1¨OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007103187-A2 | 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2007-09-13 | — | — | WO | disclosed |