Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 5/20 | 0.42 |
| ▸ | CTSB | P07858 | 8/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277711 | 0.90 | ACE (0.43) | ANO1CTSLCTSBCTSSCTSK | |
| SCHEMBL4632644 | 0.85 | ITGB1 (0.42) | SMN1; SMN2KMT2AMAPTCAPN1 | |
| SCHEMBL4632200 | 0.82 | SMN1; SMN2 (0.43) | ANO1SMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL4837212 | 0.79 | ANO1 (0.41) | ANO1CTSBSMN1; SMN2POLB | |
| SCHEMBL268660 | 0.78 | ANO1 (0.44) | ANO1CTSLCTSBCTSSCTSK | |
| Hydrochloric Acid SCHEMBL269972 | 0.78 | ANO1 (0.43) | ANO1CTSLCTSBCTSSCTSK | |
| SCHEMBL277671 | 0.77 | SMN1; SMN2 (0.40) | ANO1CTSSCTSKSMN1; SMN2MAPT | |
| SCHEMBL269012 | 0.77 | PTPN1 (0.42) | CTSLCTSBCTSSCTSK | |
| SCHEMBL269138 | 0.75 | KLK5 (0.43) | ANO1CTSLCTSBCTSSCTSK | |
| SCHEMBL4113899 | 0.75 | KLK5 (0.43) | ANO1CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |