Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.35 |
| ▸ | ITGAL | P20701 | 2/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277941 | 0.90 | ANO1 (0.39) | SMN1; SMN2ANO1MAPK1KMT2AALDH1A1 | |
| SCHEMBL4632644 | 0.83 | ITGB1 (0.42) | SMN1; SMN2MAPTKMT2ACAPN1MEN1 | |
| SCHEMBL4837212 | 0.82 | ANO1 (0.41) | SMN1; SMN2ANO1 | |
| SCHEMBL4667376 | 0.82 | ANO1 (0.45) | SMN1; SMN2ANO1MAPTKMT2AALDH1A1 | |
| SCHEMBL277671 | 0.80 | SMN1; SMN2 (0.40) | SMN1; SMN2ANO1MAPTMAPK1HTT | |
| SCHEMBL268422 | 0.79 | CTSS (0.51) | ANO1 | |
| SCHEMBL4599931 | 0.78 | LMNA (0.42) | SMN1; SMN2MAPTMAPK1KMT2AL3MBTL1 | |
| SCHEMBL270276 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2ANO1MAPTKMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL268093 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2ANO1MAPTKMT2AL3MBTL1 | |
| SCHEMBL269166 | 0.76 | ACE (0.40) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |