Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.51 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL792034 | 0.83 | TACR1 (0.52) | TACR1FFAR1FFAR4KIF11BACE1 | |
| SCHEMBL5198493 | 0.79 | PDK2 (0.53) | TACR1FFAR1FFAR4KIF11BACE1 | |
| SCHEMBL5511135 | 0.77 | KIF11 (0.50) | TACR1FFAR1FFAR4KIF11BACE1 | |
| SCHEMBL2096005 | 0.77 | KIF11 (0.50) | TACR1FFAR1FFAR4KIF11BACE1 | |
| SCHEMBL5199432 | 0.77 | KIF11 (0.50) | TACR1FFAR1FFAR4KIF11BACE1 | |
| SCHEMBL13675366 | 0.77 | KIF11 (0.50) | TACR1FFAR1FFAR4KIF11BACE1 | |
| SCHEMBL5190986 | 0.77 | FFAR4 (0.48) | TACR1FFAR1FFAR4PTGDR2CYP1A2 | |
| SCHEMBL9295043 | 0.77 | DPP4 (0.62) | TACR1FFAR1FFAR4KIF11BACE1 | |
| SCHEMBL5240718 | 0.76 | HRH1 (0.49) | TACR1ALDH1A1HTR7 | |
| SCHEMBL17840160 | 0.75 | KIF11 (0.68) | KIF11BACE1ALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930308-A1 | Pharmaceutical agents for the treatment of cerebral amyloidosis | NYMOX CORPORATION (CA) | 2008-06-11 | — | — | EP | disclosed |
| EP-0983222-B1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORP (CA) | 2007-11-28 | — | — | EP | disclosed |
| US-6518314-B1 | For treating cerebral amyloidosis; compounds that impede the transformation of dense microspheres (DMS) into amyloid | NYMOX CORPORATION (CA) | 2003-02-11 | — | — | US | disclosed |
| EP-0983222-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998052898-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 1998-11-26 | — | — | WO | disclosed |