Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32679582 | 0.90 | RAB9A (0.46) | RAB9ANPC1KMT2AHTTALDH1A1 | |
| SCHEMBL11062255 | 0.81 | TDP1 (0.47) | RAB9ANPC1KMT2AHTTALDH1A1 | |
| SCHEMBL13424123 | 0.74 | RAB9A (0.44) | RAB9ANPC1KMT2AHTTALDH1A1 | |
| SCHEMBL11195764 | 0.73 | RAB9A (0.45) | RAB9ANPC1KMT2AHTTALDH1A1 | |
| SCHEMBL11115184 | 0.73 | NPC1 (0.43) | RAB9ANPC1KMT2AHTTALDH1A1 | |
| SCHEMBL4710601 | 0.72 | HTT (0.41) | RAB9AHTTALDH1A1MAPTHPGD | |
| SCHEMBL11195753 | 0.72 | RAB9A (0.42) | RAB9ANPC1KMT2AHTTALDH1A1 | |
| SCHEMBL6208496 | 0.71 | RAB9A (0.48) | RAB9AHTTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3991174 | 0.71 | TDP1 (0.47) | RAB9AALDH1A1MAPTHPGDPOLB | |
| SCHEMBL32679563 | 0.71 | CYP1A2 (0.50) | KMT2AALDH1A1MAPTHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1988093-A1 | Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors | Wyeth a Corporation of the State of Delaware (US) | 2008-11-05 | — | — | EP | disclosed |
| EP-1885357-A1 | BICYCLIC 6-ALKYLIDENE-PENEMS AS CLASS-D BETA-LACTAMASES INHIBITORS | Wyeth (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006130588-A1 | BICYCLIC 6-ALKYLIDENE-PENEMS AS CLASS-D BETA-LACTAMASES INHIBITORS | WYETH (US) | 2006-12-07 | — | — | WO | disclosed |