Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667683 | 0.72 | RAB9A (0.46) | HTTTDP1RAB9AALDH1A1MAPT | |
| SCHEMBL3991174 | 0.71 | TDP1 (0.47) | TDP1RAB9AALDH1A1MAPTATM | |
| SCHEMBL6141087 | 0.70 | TDP1 (0.59) | TDP1RAB9AALDH1A1MAPTATM | |
| SCHEMBL10465292 | 0.70 | MAOB (0.56) | HTTRAB9AALDH1A1MAPTIDO1 | |
| SCHEMBL5724018 | 0.69 | SMN1; SMN2 (0.51) | TDP1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL11099610 | 0.69 | IDO1 (0.58) | HTTRAB9AALDH1A1MAPTIDO1 | |
| SCHEMBL32679582 | 0.69 | RAB9A (0.46) | HTTTDP1RAB9AALDH1A1MAPT | |
| SCHEMBL37664 | 0.69 | HTR2A (0.62) | HTTRAB9AALDH1A1IDO1AKR1C3 | |
| SCHEMBL6398890 | 0.69 | TDP1 (0.49) | HTTTDP1RAB9AALDH1A1MAPT | |
| SCHEMBL5723654 | 0.69 | TDP1 (0.52) | HTTTDP1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885358-A2 | TRICYCLIC 6-ALKYLIDENE-PENEMS AS CLASS-D ß-LACTAMASES INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007030166-A2 | TRICYCLIC 6-ALKYLIDENE-PENEMS AS CLASS-D β-LACTAMASES INHIBITORS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |