SCHEMBL4667723

SCHEMBL4667723

NS(=O)(=O)Oc1ccc(-c2ccc(C(=O)O)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
STS P08842 9/20 0.67
CA2 P00918 6/20 0.67
CA9 Q16790 6/20 0.67
CA1 P00915 5/20 0.67
CA12 O43570 3/20 0.59
CA14 Q9ULX7 2/20 0.59
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
NPC1 O15118 1/20 0.55
RAB9A P51151 1/20 0.55
SENP8 Q96LD8 1/20 0.55
SENP7 Q9BQF6 1/20 0.55
SENP6 Q9GZR1 1/20 0.55
KIF11 P52732 1/20 0.54
HSD17B10 Q99714 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9451332 0.94 STS (0.74) STSCA2CA9CA1
SCHEMBL4665441 0.81 STS (0.90) STSCA2CA9CA1CA12
SCHEMBL2501164 0.80 STS (1.00) STSCA2CA9CA1
SCHEMBL7263619 0.80 CA2 (1.00) STSCA2CA9CA1CA12
SCHEMBL6800066 0.79 CA2 (0.68) STSCA2CA9CA1CA12
SCHEMBL9451248 0.78 STS (1.00) STSCA2CA9CA1CA12
SCHEMBL4666145 0.76 STS (0.61) STSCA2CA9CA1CA12
SCHEMBL270225 0.76 KMT2A (0.56) STSCA2CA9CA1CA12
SCHEMBL4666147 0.76 CA2 (0.70) STSCA2CA9CA1CA12
SCHEMBL31202650 0.76 PARP15 (0.69) CA2CA1KMT2ARAB9AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1193250-B1 PHENYL SULFAMATE DERIVATIVES TEIKOKU HORMONE MFG CO LTD (JP) 2008-06-04 EP disclosed
US-6762205-B1 STEROID SULFATASE INHIBITORS WITHOUT ESTROGENIC SIDE EFFECT ACTION TEIKOKU HORMONE MFG. CO., LTD. (JP) 2004-07-13 US disclosed
EP-1193250-A1 PHENYL SULFAMATE DERIVATIVES Teikoku Hormone Mfg. Co., Ltd. (JP) 2002-04-03 EP disclosed