Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 3/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669071 | 0.89 | KDM5A (0.44) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL3653256 | 0.87 | KDM5A (0.41) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL4669117 | 0.80 | KDM5A (0.39) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL1845894 | 0.77 | CA14 (0.40) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL6895667 | 0.77 | CXCR2 (0.37) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL6897064 | 0.76 | LTA4H (0.42) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL6897170 | 0.76 | LTA4H (0.42) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL6897865 | 0.76 | CASR (0.36) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL6894998 | 0.76 | LTA4H (0.42) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL6895192 | 0.75 | CNR2 (0.38) | KDM5APHF8KDM2AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001876-A2 | 8-AZABICYCLOÝ3.2.1¨OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007103187-A2 | 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2007-09-13 | — | — | WO | disclosed |