Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 3/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667724 | 0.87 | KDM5A (0.40) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL4669117 | 0.81 | KDM5A (0.39) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL4669071 | 0.77 | KDM5A (0.44) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL11594646 | 0.74 | KDM5A (0.41) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL10323213 | 0.74 | KDM5A (0.41) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL10323234 | 0.72 | KDM5A (0.40) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL7471043 | 0.71 | ALOX5 (0.50) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL27865497 | 0.69 | TDP1 (0.42) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL28235473 | 0.69 | TDP1 (0.43) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL5510789 | 0.68 | SIGMAR1 (0.56) | KDM5APHF8KDM2AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195314-A1 | DISUBSTITUTED ALKYL-8-AZABICYCLO [3.2.1.]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009029257-A1 | DISUBSTITUTED ALKYL-8-AZABICYCLO [3.2.1.] OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2009-03-05 | — | — | WO | disclosed |