Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667740 | 1.00 | HPGD (0.52) | HPGDKMT2ATHRBSMN1; SMN2LIPG | |
| SCHEMBL4667886 | 0.89 | THRB (0.56) | HPGDKMT2ATHRBSMN1; SMN2MAPT | |
| SCHEMBL4667888 | 0.89 | THRB (0.56) | HPGDKMT2ATHRBSMN1; SMN2MAPT | |
| SCHEMBL4667875 | 0.85 | KDR (0.49) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4666551 | 0.85 | NPSR1 (0.51) | HPGDSMN1; SMN2MAPTLMNAALDH1A1 | |
| SCHEMBL4667873 | 0.85 | KDR (0.49) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4666548 | 0.85 | NPSR1 (0.51) | HPGDSMN1; SMN2MAPTLMNAALDH1A1 | |
| SCHEMBL4669121 | 0.84 | MMP1 (0.53) | KMT2ATHRBSMN1; SMN2MAPTLMNA | |
| SCHEMBL4669118 | 0.84 | MMP1 (0.53) | KMT2ATHRBSMN1; SMN2MAPTLMNA | |
| SCHEMBL4350169 | 0.82 | FGFR1 (0.56) | HPGDKMT2ATHRBSMN1; SMN2LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | claimed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | claimed |
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | disclosed |