Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667806 | 1.00 | CAMKK2 (0.37) | CAMKK2KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4667762 | 0.86 | CTSL (0.40) | KMT2ACYP1A2CYP3A4CYP2D6NEK2 | |
| SCHEMBL4667766 | 0.86 | CTSL (0.40) | KMT2ACYP1A2CYP3A4CYP2D6NEK2 | |
| SCHEMBL4667606 | 0.83 | TLR7 (0.44) | KMT2ACYP1A2CYP3A4CYP2C9RPS6KB1 | |
| SCHEMBL4667611 | 0.83 | TLR7 (0.44) | KMT2ACYP1A2CYP3A4CYP2C9RPS6KB1 | |
| SCHEMBL5257623 | 0.77 | KMT2A (0.54) | CAMKK2KMT2ANEK2PLK1MET | |
| SCHEMBL5258592 | 0.77 | KMT2A (0.54) | CAMKK2KMT2ANEK2PLK1MET | |
| SCHEMBL5257618 | 0.77 | KMT2A (0.54) | CAMKK2KMT2ANEK2PLK1MET | |
| SCHEMBL10126734 | 0.75 | KMT2A (0.40) | CAMKK2KMT2AKDRMETLCK | |
| SCHEMBL4667699 | 0.74 | CAMKK2 (0.38) | CAMKK2KMT2ANEK2PLK1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | claimed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | claimed |
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | disclosed |