Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24378643 | 0.69 | KMT2A (0.51) | NOTUMMAPTALDH1A1SMN1; SMN2BRD4 | |
| SCHEMBL19626484 | 0.67 | TSHR (0.57) | NOTUMMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3631400 | 0.67 | FGFR1 (0.54) | NOTUMMAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL30963937 | 0.66 | RXRA (0.51) | NOTUMMAPTBRD4BRD2CREBBP | |
| SCHEMBL4667063 | 0.66 | ALDH1A1 (0.61) | MAPTALDH1A1SMN1; SMN2NPC1NFKB1 | |
| SCHEMBL9260410 | 0.66 | RXRA (0.66) | NOTUMMAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL29426410 | 0.66 | RXRA (0.66) | NOTUMMAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL11523724 | 0.66 | NOTUM (0.52) | NOTUMMAPTSMN1; SMN2BRD4BRD2 | |
| SCHEMBL17626237 | 0.66 | MAPT (0.49) | NOTUMMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL26253637 | 0.65 | TP53 (0.44) | NOTUMMAPTALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928455-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | Bayer Healthcare, LLC (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |