Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11002350 | 0.76 | TP53 (0.36) | TP53HBBSMN1; SMN2 | |
| SCHEMBL6428865 | 0.75 | KDM4E (0.31) | — | |
| SCHEMBL18637502 | 0.75 | PIK3CD (0.36) | — | |
| SCHEMBL5603511 | 0.75 | TP53 (0.35) | TP53HBBSMN1; SMN2 | |
| SCHEMBL4668740 | 0.73 | TP53 (0.35) | TP53HBBSMN1; SMN2 | |
| SCHEMBL23751025 | 0.73 | ATAD2 (0.33) | — | |
| SCHEMBL27717165 | 0.73 | F2 (0.36) | — | |
| Hydrochloric Acid SCHEMBL4493765 | 0.72 | F2 (0.38) | — | |
| SCHEMBL23751043 | 0.72 | POLB (0.42) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL10975707 | 0.70 | ATAD2 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902053-A2 | BENZOIMIDAZOLONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | Theravance, Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2006133104-A2 | BENZOIMIDAZOLONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2006-12-14 | — | — | WO | disclosed |