Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28231353 | 0.80 | KDM4E (0.33) | KDM4EHTR2AHTR2CMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL3182984 | 0.78 | DPP4 (0.34) | KDM4EMAPTKMT2AATMCYP2D6 | |
| Hydrochloric Acid SCHEMBL3182976 | 0.78 | DPP4 (0.34) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL23751025 | 0.78 | ATAD2 (0.33) | — | |
| SCHEMBL27717165 | 0.78 | F2 (0.36) | — | |
| SCHEMBL18637502 | 0.77 | PIK3CD (0.36) | KDM4E | |
| Hydrochloric Acid SCHEMBL4493765 | 0.76 | F2 (0.38) | — | |
| SCHEMBL4747560 | 0.75 | DPP4 (0.39) | KDM4E | |
| SCHEMBL4667961 | 0.75 | TP53 (0.36) | — | |
| SCHEMBL3624075 | 0.75 | CA1 (0.34) | KDM4EMAPTKMT2AATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |