Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TACR3 | P29371 | 6/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668167 | 0.94 | LMNA (0.74) | LMNATP53TACR3CNR1NPC1 | |
| SCHEMBL4665602 | 0.83 | LMNA (0.57) | LMNATP53TACR3TACR2 | |
| SCHEMBL3870523 | 0.83 | LMNA (0.65) | LMNAL3MBTL1TP53TACR3CACNA1B | |
| SCHEMBL16553849 | 0.82 | LMNA (0.67) | LMNAL3MBTL1TP53TACR3CNR1 | |
| Hydrochloric Acid SCHEMBL5499021 | 0.82 | LMNA (0.64) | LMNAL3MBTL1TP53TACR3CACNA1B | |
| SCHEMBL5047970 | 0.82 | LMNA (0.67) | LMNAL3MBTL1TP53TACR3CACNA1B | |
| SCHEMBL5049830 | 0.82 | LMNA (0.67) | LMNAL3MBTL1TP53TACR3CNR1 | |
| SCHEMBL5045806 | 0.81 | LMNA (0.66) | LMNAL3MBTL1TP53TACR3CACNA1B | |
| SCHEMBL4667123 | 0.81 | LMNA (0.66) | LMNAL3MBTL1TP53TACR3CACNA1B | |
| SCHEMBL5045993 | 0.81 | LMNA (0.66) | LMNAL3MBTL1TP53TACR3CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891012-A2 | QUINOLINE DERIVATIVES AS NK3 ANATGONISTS | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | claimed |
| WO-2006130080-A2 | QUINOLINE DERIVATIVES AS NK3 ANATGONISTS | ASTRAZENECA AB (SE) | 2006-12-07 | — | — | WO | claimed |
| EP-1891012-A2 | QUINOLINE DERIVATIVES AS NK3 ANATGONISTS | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006130080-A2 | QUINOLINE DERIVATIVES AS NK3 ANATGONISTS | ASTRAZENECA AB (SE) | 2006-12-07 | — | — | WO | disclosed |