Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768465 | 0.90 | PLA2G2A (0.58) | PLA2G2AMAPTTP53LMNAALDH1A1 | |
| SCHEMBL9056926 | 0.85 | LMNA (0.58) | TP53LMNAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL2003405 | 0.78 | SERPINE1 (0.59) | PLA2G2AMAPTLMNAALDH1A1SERPINE1 | |
| SCHEMBL4668109 | 0.77 | PLA2G2A (0.46) | PLA2G2ATP53LMNAALDH1A1L3MBTL1 | |
| SCHEMBL4665211 | 0.76 | SLC22A6 (0.43) | MAPTTP53LMNAALDH1A1L3MBTL1 | |
| SCHEMBL27923785 | 0.76 | CYP3A4 (0.40) | ALDH1A1GAAKDM4E | |
| SCHEMBL2008137 | 0.75 | PLA2G2A (0.65) | PLA2G2ALMNAALDH1A1SERPINE1 | |
| SCHEMBL28774126 | 0.75 | PLA2G2A (0.49) | PLA2G2ALMNAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL9030278 | 0.74 | LMNA (0.61) | MAPTTP53LMNAALDH1A1GAA | |
| SCHEMBL9056108 | 0.74 | LMNA (0.55) | PLA2G2AMAPTTP53LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102850324-A | Indole compounds | MICROBIA INC | 2013-01-02 | — | — | CN | disclosed |
| CN-101563337-A | Indole compounds | MICROBIA INC (US) | 2009-10-21 | — | — | CN | disclosed |
| EP-1931632-A2 | USEFUL INDOLE COMPOUNDS | Microbia Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007022501-A2 | USEFUL INDOLE COMPOUNDS | MICROBIA, INC. (US) | 2007-02-22 | — | — | WO | disclosed |