Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | ADH5 | P11766 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30558759 | 0.89 | ALDH1A1 (0.71) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL30305324 | 0.83 | ADH5 (0.66) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL8268417 | 0.83 | ALDH1A1 (0.65) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL2048531 | 0.80 | ALDH1A1 (0.61) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL1073638 | 0.80 | ALDH1A1 (0.61) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL10901719 | 0.80 | ALDH1A1 (0.61) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL265184 | 0.80 | ALDH1A1 (0.61) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL9451418 | 0.80 | ALDH1A1 (0.61) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL2336960 | 0.79 | CYP3A4 (0.69) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 | |
| SCHEMBL10900022 | 0.78 | ALDH1A1 (0.54) | ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020233512-A1 | AROMATIC AMINE AR AND BET TARGETING PROTEIN DEGRADATION CHIMERA COMPOUND AND USE | 成都海创药业有限公司 (CN) | 2020-11-26 | — | — | WO | disclosed |
| WO-2017155991-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-09-14 | — | — | WO | disclosed |
| EP-1802307-B1 | PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS | GLAXO GROUP LTD (GB) | 2008-02-27 | — | — | EP | disclosed |
| US-20080045506-A1 | Pyrrolidine Derivatives as Histamine Receptors Ligands | GLAXO GROUP LIMITED (GB) | 2008-02-21 | — | — | US | disclosed |
| EP-1802307-A1 | PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS | GLAXO GROUP LIMITED (GB) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040192-A1 | PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS | GLAXO GROUP LIMITED (GB) | 2006-04-20 | — | — | WO | disclosed |
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| EP-0863905-B1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER (US) | 2000-11-29 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| US-6037355-A | ANTIINFLAMMATORY AGENTS AND ANTIALLERGENS; CARDIOVASCULAR DISORDERS | PFIZER INC (US) | 2000-03-14 | — | — | US | disclosed |
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0863905-A1 | NOVEL IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1997011079-A1 | NOVEL IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1997-03-27 | — | — | WO | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045506-A1 | Pyrrolidine Derivatives as Histamine Receptors Ligands | HRH4, HRH3, HRH2 | ALDH1A1 1039/4885CYP3A4 1860/4885CYP2D6 1105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.