SCHEMBL4668567

SCHEMBL4668567

CCN(C(=O)c1c(C[N+]2([O-])CCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1C#N

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TACR3 P29371 8/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
PDE10A Q9Y233 3/20 0.35
TSHR P16473 2/20 0.35
TACR2 P21452 4/20 0.35
LMNA P02545 3/20 0.35
TP53 P04637 1/20 0.35
OPRM1 P35372 1/20 0.35
DHODH Q02127 2/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4668577 0.93 TACR3 (0.36) TACR3KDM4EALDH1A1L3MBTL1PDE10A
SCHEMBL4668624 0.92 TACR3 (0.38) TACR3KDM4EALDH1A1L3MBTL1TSHR
SCHEMBL4665272 0.85 TSHR (0.47) TACR3KDM4EALDH1A1L3MBTL1PDE10A
SCHEMBL4665277 0.85 TSHR (0.46) TACR3KDM4EALDH1A1L3MBTL1PDE10A
SCHEMBL4668635 0.80 TACR3 (0.43) TACR3PDE10ATSHR
SCHEMBL4665269 0.79 TACR3 (0.42) TACR3PDE10ATSHRTACR2
SCHEMBL4667074 0.79 TACR3 (0.53) TACR3KDM4EALDH1A1TSHRTACR2
SCHEMBL4667103 0.78 TSHR (0.47) TACR3PDE10ATSHRTACR2LMNA
SCHEMBL4665731 0.77 TACR3 (0.41) TACR3ALDH1A1TSHRTACR2TP53
SCHEMBL4665925 0.77 TACR3 (0.40) TACR3ALDH1A1L3MBTL1TACR2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940795-A1 N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS AstraZeneca AB (SE) 2008-07-09 EP disclosed
WO-2007035156-A1 N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS ASTRAZENECA AB (SE) 2007-03-29 WO disclosed