Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 14/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | TACR2 | P21452 | 8/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668624 | 0.85 | TACR3 (0.38) | TACR3KCNH2TACR2KDM4EALDH1A1 | |
| SCHEMBL4668567 | 0.79 | TACR3 (0.37) | TACR3TACR2OPRM1KDM4EALDH1A1 | |
| SCHEMBL4667075 | 0.78 | TACR3 (0.57) | TACR3KCNH2TACR2OPRM1 | |
| SCHEMBL4668577 | 0.77 | TACR3 (0.36) | TACR3KCNH2TACR2OPRM1KDM4E | |
| SCHEMBL28773315 | 0.76 | TACR3 (0.55) | TACR3KCNH2TACR2OPRM1 | |
| SCHEMBL4667051 | 0.75 | TACR3 (0.55) | TACR3KCNH2TACR2OPRM1 | |
| SCHEMBL6996763 | 0.74 | TACR3 (0.54) | TACR3KCNH2TACR2OPRM1 | |
| SCHEMBL6266946 | 0.72 | TACR2 (0.59) | TACR3KCNH2TACR2OPRM1TSHR | |
| SCHEMBL6848956 | 0.72 | TACR2 (0.61) | TACR3KCNH2TACR2OPRM1TSHR | |
| SCHEMBL6853049 | 0.71 | TACR3 (0.58) | TACR3KCNH2TACR2OPRM1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940795-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007035156-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |