Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 10/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 4/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668567 | 0.93 | TACR3 (0.37) | TACR3TSHRKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4668624 | 0.89 | TACR3 (0.38) | TACR3TSHRKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4667103 | 0.86 | TSHR (0.47) | TACR3TSHRKCNH2TACR2PDE10A | |
| SCHEMBL4667476 | 0.81 | TACR3 (0.41) | TACR3TSHRKCNH2PDE10A | |
| SCHEMBL4667067 | 0.78 | TACR3 (0.40) | TACR3TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL4665272 | 0.78 | TSHR (0.47) | TACR3TSHRKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4668578 | 0.78 | LMNA (0.48) | TACR3TSHRALDH1A1KCNH2TACR2 | |
| SCHEMBL4667074 | 0.77 | TACR3 (0.53) | TACR3TSHRKDM4EALDH1A1KCNH2 | |
| SCHEMBL4665218 | 0.77 | TACR3 (0.44) | TACR3ALDH1A1L3MBTL1KCNH2TACR2 | |
| SCHEMBL4665277 | 0.77 | TSHR (0.46) | TACR3TSHRKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940795-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-07-09 | — | — | EP | claimed |
| WO-2007035156-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |